Thermo Fisher Scientific Corona Veo, Corona Veo RS Mode d'emploi

Thermo Scientific

Charged Aerosol

Detectors

Corona Veo, Corona Veo RS

Operating Manual

4820.8101 Revision 2.1 • October 2019

thermoscientific

Original Operating Manual

The hardware descriptions in this manual revision refer to devices Corona Veo and Corona Veo

RS. For the manual release history, see page 251.

Trademarks

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All other trademarks are property of Thermo Fisher Scientific and its subsidiaries.

Thermo Fisher Scientific Inc. provides this document to its customers with a product purchase to

use in the product operation. The document is copyright protected; any reproduction of the

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of Thermo Fisher Scientific Inc.

This manual is provided "as is." The contents of this manual are subject to being changed,

without notice, in future revisions.

Thermo Fisher Scientific Inc. makes no representations that this document is complete,

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even if the information in the document is followed properly.

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documents.

Printed manual version only

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environmentally friendly process, leading to a paper profile of zero CO2 emissions.

Manufacturer's address

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Dornierstrasse 4, D-82110 Germering

Contacting Us

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 3

Contacting Us

There are several ways to contact us:

Ordering Information

For ordering information or sales support for HPLC products, contact

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information, go to Contact Us on http://www.thermofisher.com.

Technical Assistance

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Page 4 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

Contents

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 5

Contents

1 Using this Manual ...........................................................................11

1.1 About this Manual ................................................................................................ 12

1.2 Conventions .......................................................................................................... 13

1.2.1 Safety Messages ....................................................................................... 13

1.2.2 Special Notices and Informational Notes ................................................. 13

1.2.3 Typographical Conventions ...................................................................... 14

1.3 Reference Documentation .................................................................................... 15

2 Safety ..............................................................................................17

2.1 Safety Symbols and Signal Words ......................................................................... 18

2.1.1 Safety Symbols and Signal Words in This Manual ................................... 18

2.1.2 Observing this Manual ............................................................................. 19

2.1.3 Safety Symbols on the Detector .............................................................. 20

2.1.4 Rating Plate .............................................................................................. 21

2.2 Intended Use ......................................................................................................... 22

2.3 Safety Precautions ................................................................................................ 23

2.3.1 General Safety Information ..................................................................... 23

2.3.2 Qualification of the Personnel ................................................................. 25

2.3.3 Personal Protective Equipment ............................................................... 27

2.3.4 Electrical Safety Precautions .................................................................... 29

2.3.5 General Residual Hazards ........................................................................ 30

2.3.6 In Case of Emergency ............................................................................... 36

2.4 Solvent and Additive Information ......................................................................... 37

2.5 Compliance Information ....................................................................................... 38

3 Detector Overview ..........................................................................39

3.1 Detector Features ................................................................................................. 40

3.2 Operating Principle ............................................................................................... 41

3.3 Interior Front Components ................................................................................... 43

3.4 Nebulizer ............................................................................................................... 44

3.5 Gas Filter Assembly ............................................................................................... 44

3.6 Excess Liquid and Leak Detection ......................................................................... 45

3.7 Software Operation .............................................................................................. 46

Contents

Page 6 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

4 Unpacking ....................................................................................... 47

4.1 Unpacking ............................................................................................................ 48

4.2 Scope of Delivery ................................................................................................. 50

5 Installation ...................................................................................... 51

5.1 Safety Guidelines for Installation ......................................................................... 52

5.2 Installing the Detector ......................................................................................... 53

5.3 Site Requirements ................................................................................................ 55

5.3.1 Workbench .............................................................................................. 55

5.3.2 Power Considerations ............................................................................. 55

5.3.3 Power Cord .............................................................................................. 57

5.3.4 Condensation .......................................................................................... 58

5.3.5 Operating Conditions .............................................................................. 59

5.3.6 Gas Ventilation ........................................................................................ 60

5.3.7 Gas Supply ............................................................................................... 61

5.4 Accessing the Front Components ........................................................................ 66

5.5 Setting Up the Hardware ..................................................................................... 67

5.5.1 System Arrangement with an UltiMate 3000 System ............................. 67

5.5.2 Setting Up Cable Connections to the Detector ....................................... 69

5.5.3 Nebulizer Installation .............................................................................. 77

5.5.4 Connecting the Gas Inlet and Exhaust Tubes .......................................... 79

5.6 Setting Up the Liquid Flow Connections .............................................................. 81

5.6.1 Guidelines and Overview of Actions ....................................................... 81

5.6.2 Connecting Fittings, Capillaries, and Tubing ........................................... 83

5.6.3 Setting Up the Detector Drainage ........................................................... 86

5.6.4 Installing the In-Line Filter (optional) ...................................................... 90

5.6.5 Connecting the Detector in the System Flow Path ................................. 91

5.6.6 Connecting the Stream-Switching Valve (Corona Veo RS only) .............. 96

5.7 Turning On the Detector ...................................................................................... 98

6 Operation ..................................................................................... 101

6.1 Introduction to this Chapter .............................................................................. 102

6.2 Safety Guidelines for Operation ........................................................................ 103

6.3 Control Elements and Status Indicator .............................................................. 106

6.4 Touch Screen Display ......................................................................................... 107

6.4.1 Main Menu ............................................................................................ 109

Contents

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 7

6.4.2 Run Mode Menu .................................................................................... 110

6.4.3 System Setup Menu ............................................................................... 115

6.5 Preparing the Detector for Operation ................................................................ 121

6.5.1 Mobile Phase Guidelines for the Detector............................................. 123

6.5.2 Setting the Nebulizer Gas Pressure ........................................................ 129

6.5.3 Equilibrating the System ........................................................................ 133

6.5.4 Detector Equilibration ............................................................................ 135

6.6 Operating the Detector ....................................................................................... 138

6.7 Optimizing the Performance............................................................................... 140

6.7.1 Optimization Guidelines ........................................................................ 140

6.7.2 Overview of Optimization Parameters .................................................. 141

6.7.3 Filter Constant ........................................................................................ 142

6.7.4 Evaporation Temperature ...................................................................... 142

6.7.5 Gas Regulation Mode (Corona Veo RS Detector only) ........................... 144

6.7.6 Power Function Value ............................................................................ 145

6.7.7 Baseline Noise ........................................................................................ 146

6.7.8 Data Collection Rate............................................................................... 146

6.8 Software Operation ............................................................................................ 148

6.8.1 Setting Up the Detector in the Software ............................................... 148

6.8.2 Operating the Detector from the Software ........................................... 150

6.8.3 Signal Channels in Chromeleon ............................................................. 156

6.8.4 Chromeleon Audit Trail .......................................................................... 157

6.9 Shutting Down the Detector ............................................................................... 159

6.9.1 Short-Term Shutdown (Interruption of Operation) ............................... 159

6.9.2 Long-Term Shutdown ............................................................................. 160

7 Maintenance and Service .............................................................. 163

7.1 Introduction to Maintenance and Service .......................................................... 164

7.2 Safety Guidelines for Maintenance and Service ................................................. 165

7.3 General Rules for Maintenance and Service ...................................................... 169

7.4 Routine and Preventive Maintenance ................................................................ 170

7.4.1 Maintenance Plan .................................................................................. 170

7.4.2 Preventive Maintenance ........................................................................ 171

7.4.3 Flushing the Detector between Analyses .............................................. 172

7.4.4 Cleaning or Decontaminating the Detector ........................................... 173

7.5 Disconnecting the Gas Inlet and Exhaust Tubes ................................................. 176

Contents

Page 8 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

7.6 Disconnecting the Drain Lines ............................................................................ 178

7.7 Removing the Nebulizer ..................................................................................... 179

7.8 Replacing the Gas Filter Assembly ..................................................................... 183

7.9 Stream-Switching Valve (Corona Veo RS only) .................................................. 192

7.9.1 Disassembling and Inspecting the Valve ............................................... 192

7.9.2 Cleaning Stator and Rotor ..................................................................... 194

7.9.3 Reassembling the Valve ........................................................................ 194

7.10 Replacing the Main Power Fuses ....................................................................... 196

7.11 Updating the Detector Firmware ....................................................................... 198

7.12 Removing the Detector from the System Stack ................................................. 200

7.13 Transporting or Shipping the Detector .............................................................. 202

7.13.1 Preparing the Detector for Transport ................................................... 203

7.13.2 Transporting the Detector to a New Location ...................................... 203

7.13.3 Shipping the Detector ........................................................................... 204

8 Troubleshooting ............................................................................ 207

8.1 General Information about Troubleshooting .................................................... 208

8.2 Troubleshooting Check ...................................................................................... 210

8.3 Self-Test Error Codes .......................................................................................... 212

8.4 Warning and Error Codes ................................................................................... 214

8.4.1 Warning Codes ...................................................................................... 214

8.4.2 Error Codes ............................................................................................ 216

8.5 Operating Issues ................................................................................................. 220

8.5.1 Resolving Leakage ................................................................................. 220

8.5.2 Resolving Gas Supply Overpressure ...................................................... 222

8.5.3 Resolving Flooding In the Detector ....................................................... 224

8.5.4 Additional Operating Issues .................................................................. 225

9 Specifications ................................................................................ 235

9.1 Performance Specifications ............................................................................... 236

9.2 Physical Specifications ....................................................................................... 238

10 Accessories, Consumables and Replacement Parts ...................... 239

10.1 General Information .......................................................................................... 240

Contents

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 9

10.2 Ship Kit ................................................................................................................ 241

10.2.1 Corona Veo RS Detector ........................................................................ 241

10.2.2 Corona Veo Detector ............................................................................. 242

10.3 Optional Accessories ........................................................................................... 244

10.4 Consumables and Replacement Parts ................................................................ 245

11 Appendix ..................................................................................... 247

11.1 Compliance Information ..................................................................................... 248

11.1.1 Declarations of Conformity .................................................................... 248

11.1.2 WEEE Compliance .................................................................................. 250

11.1.3 FCC Compliance ..................................................................................... 251

11.1.4 Manual Release History ......................................................................... 251

11.2 Digital I/O Terminals Pin Assignment ................................................................. 252

11.2.1 TTL Inputs ............................................................................................... 253

11.2.2 Relay Outputs ......................................................................................... 254

11.3 Internal Gas Flow Path Diagram ......................................................................... 255

12 Index ........................................................................................... 257

Contents

Page 10 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

1 • Using this Manual

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 11

1 Using this Manual

This chapter provides information about this manual, the conventions used

throughout the manual, and the reference documentation that is available

in addition to this manual.

1 • Using this Manual

Page 12 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

1.1 About this Manual

This manual describes the functional features and operating principle of

your Thermo Scientific™ Corona™ Veo™ and Corona Veo RS detector

and provides instructions for installation, set up, start up, shut down,

operation, maintenance and troubleshooting.

The layout of this manual is designed to provide quick reference to the

sections of interest to the user. To obtain a full understanding of your

detector, read this manual thoroughly.

This manual also contains safety messages, precautionary statements,

and special notices that can prevent personal injury, damage to the

detector, or loss of data when followed properly.

Note the following:

• The detector configuration may vary; therefore, not all descriptions

necessarily apply to your particular detector.

• If some detail applies to only one model or variant, the model or

variant is identified by name.

• Illustrations in this manual are provided for basic understanding.

They can vary from the actual model of the detector or component.

However, this does not influence the descriptions. No claims can be

derived from the illustrations in this manual.

The descriptions in this manual assume that the detector is installed in

the HPLC system stack. If this is not the case, additional hardware is

required and must be ordered separately. The information in this

manual applies correspondingly.

1 • Using this Manual

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 13

1.2 Conventions

This section describes the conventions that are used throughout this

manual.

1.2.1 Safety Messages

The safety messages and precautionary statements in this manual

appear as follows:

• Safety messages or precautionary statements that apply to the

entire manual and all procedures in this manual are grouped in the

Safety chapter.

• Safety messages or precautionary statements that apply to an entire

section or to multiple procedures in a section appear at the

beginning of the section to which they apply.

• Safety messages that apply to only a particular section or procedure

appear in the section or procedure to which they apply. They appear

different from the main flow of text.

Safety messages are often preceded by an alert symbol and/or alert

word. The alert word appears in uppercase letters and in bold type.

Make sure that you understand and follow all safety messages

presented in this manual.

1.2.2 Special Notices and Informational Notes

Special notices and informational notes in this manual appear different

from the main flow of text. They appear in boxes and a note label

identifies them. The label text appears in uppercase letters and in bold

type.

NOTICE Highlights information necessary to prevent damage to the

detector or invalid test results.

AVIS Signale des renseignements jugés nécessaires pour éviter toute

détérioration du détecteur ou tout résultat de tests erroné.

TIP Highlights information of general interest or helpful information that

can make a task easier or optimize the performance of the detector.

1 • Using this Manual

Page 14 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

1.2.3 Typographical Conventions

These typographical conventions apply to the descriptions in this

manual:

Data Input and Output

• The following appears in bold type:

♦ Input that you enter by the keyboard or that you select with the

mouse

♦ Buttons that you click on the screen

♦ Commands that you enter by the keyboard

♦ Names of, for example, dialog boxes, properties, and parameters

• For brevity, long expressions and paths appear in the condensed

form, for example: Click Start > All Programs > Thermo

Chromeleon 7 > Services Manager > Start Instrument Controller.

References and Messages

• References to additional documentation appear italicized.

• Messages that appear on the screen are identified by quotation

marks.

Viewpoint

If not otherwise stated, the expressions left and right in this manual

always refer to the viewpoint of a person that is facing the detector from

the front.

Particularly Important Words

Particularly important words in the main flow of text appear italicized.

Electronic Manual Version (PDF)

The electronic version (PDF) of the manual contains numerous links that

you can click to go to other locations within the manual. These include:

• Table of contents entries

• Index entries

• Cross-references (in blue text), for example, to sections and figures

1 • Using this Manual

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 15

1.3 Reference Documentation

In addition to this operating manual, other documentation is available

for reference.

Hardware Documentation

Additional hardware documentation includes the following:

• Operating manuals for the other modules of the HPLC system

• Instrument Installation Qualification Operating Instructions

TIP Electronic versions of these manuals are available as PDF (Portable

Document Format) files. To open and read the PDF files, Adobe™

Reader™ or Adobe™ Acrobat™ is required.

Software Documentation

Additional software documentation includes the following:

• Chromeleon™ 7 Help and documents

The Chromeleon 7 Help provides extensive information and

comprehensive reference material for all aspects of the software.

For basic information about device installation and configuration,

refer to the Installation Guide; for specific information about a

certain device, refer to the Instrument Configuration Manager Help.

In Chromeleon 7, devices are called modules.

For information about the main elements of the user interface and

step-by-step guidance through the most important workflows, refer

to the Quick Start Guide.

For a concise overview of the most important workflows, refer to

the Reference Card.

• Chromeleon™ 6.8 Help

The Chromeleon 6.8 Help provides extensive information for all

aspects of the software, including device installation and

configuration.

TIP The Chromeleon Help and documents are included in the software

shipment.

1 • Using this Manual

Page 16 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

Third-Party Documentation

Refer also to the user documentation provided by the manufacturers of

third-party components and materials, for example, Safety Data Sheets

(SDSs).

Third-party documentation includes the user documentation for the gas

supply, as applicable:

• User documentation for the nitrogen generator

• User documentation for the air compressor

2 • Safety

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 17

2 Safety

This chapter provides general and specific safety information and informs

about the intended use of the detector.

2 • Safety

Page 18 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

2.1 Safety Symbols and Signal Words

2.1.1 Safety Symbols and Signal Words in This Manual

English Version

This manual contains safety messages to prevent injury of the persons

using the detector. The safety symbols and signal words in this manual

include the following:

Always be aware of the safety information. Do not proceed until you

have fully understood the information and consider the consequences of

what you are doing.

CAUTION Indicates a hazardous situation that, if not avoided, could

result in minor or moderate injury.

WARNING Indicates a hazardous situation that, if not avoided, could

result in serious injury.

French Version

Ce manuel comporte des consignes de sécurité afin de prévenir tout

risque de blessure pour les personnes utilisant le détecteur. Les

symboles de sécurité et mots d’avertissement du présent manuel sont

notamment :

Soyez toujours attentif aux consignes de sécurité. N’utilisez pas

l’instrument sans avoir compris l’intégralité des consignes de sécurité et

réfléchi aux conséquences de vos actions.

ATTENTION Signale une situation de danger potentiel qui, si elle n’est

pas évitée, pourrait entraîner des blessures mineures à modérées.

AVERTISSEMENT Signale une situation de danger potentiel qui, si elle

n’est pas évitée, pourrait entraîner des blessures graves.

2 • Safety

Charged Aerosol Detectors Corona Veo (RS) Operating Manual Page 19

2.1.2 Observing this Manual

English Version

Observe the following:

• Before installing or operating the detector, read this manual

carefully to be familiar with the detector and this manual. The

manual contains important information with regard to user safety as

well as use and care of the detector.

• Always keep the manual near the detector for quick reference.

• Save this manual and pass it on to any subsequent user.

Read, understand, and comply with all safety messages and

precautionary statements presented in this manual.

French Version

Respectez les consignes suivantes :

• Lisez le présent manuel attentivement avant toute installation ou

utilisation du détecteur afin de vous familiariser avec le détecteur et

avec le manuel. Ce manuel comporte des informations importantes

relatives à la sécurité des utilisateurs, ainsi qu’à l’utilisation et à la

maintenance du détecteur.

• Gardez toujours le manuel à proximité du détecteur afin de pouvoir

vous y reporter rapidement.

• Conservez ce manuel et transmettez-le à tous les utilisateurs

ultérieurs.

Lisez, comprenez et respectez tous les messages de sécurité et mentions

de mise en garde figurant dans le présent manuel.

2 • Safety

Page 20 Charged Aerosol Detectors Corona Veo (RS) Operating Manual

2.1.3 Safety Symbols on the Detector

English Version

The table lists the safety symbols that appear on the detector or on

labels affixed to the detector. Follow the safety notices in this manual to

prevent the risk of operator injury or damage to the detector.

Symbol Description

Indicates a potential hazard. Refer to this manual to avoid the risk of

personal injury and/or to prevent damage to the device.

Ο — Power supply is off Power supply is on

Indicates alternating current.

Indicates a terminal for protective grounding.

Indicates a terminal for functional grounding

French Version

Ce tableau répertorie les symboles de sécurité qui apparaissent sur le

détecteur ou sur les étiquettes apposées sur celui-ci. Conformez-vous à

tous les avis de sécurité présents dans ce manuel afin d’éviter tout

risque de blessure de l’opérateur ou de détérioration du détecteur.

Symbole Description

Indique un danger potentiel. Référez-vous à ce manuel afin d’éviter

tout risque d’accident corporel et/ou de dommage à l’appareil.

Ο — L’appareil est mis hors tension L’appareil est mis sous tension

Indique un courant alternatif.

Indique une mise à la terre de protection

Indique une mise à la terre fonctionnelle

˜

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